GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2806864 | 1 | rs2249984 | chr1:117469322 | SLC22A15 | chr1:116519119-116612672:+ | -0.59 | -4.39 | 2.96E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs2806864 | 1 | rs2250096 | chr1:117468983 | SLC22A15 | chr1:116519119-116612672:+ | -0.59 | -4.39 | 2.96E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs2806864 | 1 | rs2250439 | chr1:117466050 | SLC22A15 | chr1:116519119-116612672:+ | -0.59 | -4.39 | 2.96E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs2806864 | 1 | rs2250445 | chr1:117465904 | SLC22A15 | chr1:116519119-116612672:+ | -0.56 | -4.27 | 4.6E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs2806864 | 1 | rs2250448 | chr1:117465862 | SLC22A15 | chr1:116519119-116612672:+ | -0.59 | -4.39 | 2.96E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs9369898 | 1 | rs2251115 | chr6:49446509 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.12 | 1.57E-6 | Homocysteine levels |
| THYM | cis | rs2251844 | 1 | rs2251844 | chr15:43836478 | ADAL | chr15:43622872-43646094:+ | -0.62 | -5.23 | 1.01E-6 | Tumor biomarkers |
| THYM | cis | rs2564921 | 1 | rs2253209 | chr3:53115160 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.99 | 2.68E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2253656 | chr3:53119099 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.99 | 2.68E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2253685 | chr3:53119703 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.99 | 2.68E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2253796 | chr3:53120098 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.99 | 2.68E-6 | Height |
| THYM | cis | rs2806864 | 1 | rs2254224 | chr1:117457864 | SLC22A15 | chr1:116519119-116612672:+ | -0.58 | -4.55 | 1.58E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs7849270 | 1 | rs2254230 | chr9:131905177 | CRAT | chr9:131857075-131873070:- | -0.47 | -5.4 | 4.92E-7 | Blood metabolite ratios |
| THYM | cis | rs2251844 | 1 | rs2255042 | chr15:43834318 | ADAL | chr15:43622872-43646094:+ | 0.64 | 5.26 | 8.99E-7 | Tumor biomarkers |
| THYM | cis | rs2251844 | 1 | rs2255051 | chr15:43846161 | ADAL | chr15:43622872-43646094:+ | -0.64 | -5.26 | 8.99E-7 | Tumor biomarkers |